Alice Ryba, MD
Alice Senta Ryba, MD, Dr. med., is a short-term postdoctoral fellow from University Medical Center Hamburg-Eppendorf (UKE), Germany. She is currently a PGY-5 resident in Neurosurgery and clinician-scientist in the Laboratory of Tumor Biology within the CNS Tumor Immunology group led by PD Dr. Malte Mohme.
Her research focuses on immune escape mechanisms in glioblastoma and other central nervous system malignancies. In particular, she investigates tumor–immune interactions, systemic and local T cell dysfunction, and strategies to restore effective anti-tumor immunity. Her work integrates immune phenotyping of tumor-specific T cell responses (flow cytometry, RNA sequencing), high-dimensional plasma proteomics and epigenetic modulation of T cells (ATAC-seq) to characterize tumor-induced immunosuppression and identify potential therapeutic targets.
At UCSF, she is expanding her work in translational tumor immunology with a focus on advancing immune-based therapies for brain tumors.
University Medical Center Hamburg-Eppendorf (UKE), Germany
2024 Poster prize, Annual Meeting, German Society of Endocrinology
2025 Best thesis award 2025, Hamburg Center of NeuroScience
Somatic mutations in HLA class genes and antigen presenting molecules in malignant glioma.
Schulte SC, Peter W, Rosenberger G, Schäfer M, Maire CL, Rünger A, Ryba A, Riecken K, Fita KD, Matschke J, Akyüz N, Dierlamm J, Klau GW, Ricklefs FL, Gempt J, Westphal M, Lamszus K, Dilthey A, Mohme M.
Cancer Immunology Research, 2025, doi: 10.1158/2326-6066
Results from a European multicenter study.
Detomas M, Altieri B, Nasi-Kordhishti I, Ryba A, (..), Honegger J, Losa M.Recovery of hypopituitarism in macroprolactinomas: a comparison of medical vs. surgical treatment.
Journal Endocrinological Investigation, 2025, doi: 10.1007/s40618-025-02559-8
Insights from a multicenter study on adult H3 K27M-mutated glioma: Surgical resection's limited influence on overall survival, ATRX as molecular prognosticator.
Ryba A, Özdemir Z, Nissimov N, Hönikl L, Neidert N, Jakobs M, Kalasauskas D, Krigers A, Thomé C, Freyschlag CF, Ringel F, Unterberg A, Dao Trong P, Beck J, Heiland DH, Meyer B, Vajkoczy P, Onken J, Stummer W, Suero Molina E, Gempt J, Westphal M, Schüller U, Mohme M.
Neuro Oncology, 2024, doi: 10.1093/neuonc/noae061
A prognostic neural epigenetic signature in high-grade glioma.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire CL, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers AK, Neumann JE, Bode H, Hausmann F, Huber TB, Bonn S, Jütten K, Delev D, Weber KJ, Harter PN, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller PC, Sahm F, Menstel JA, Zimmer DN, Keough MB, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà ML, Krishna S, Hervey-Jumper SL, Schüller U, Heiland DH, Hänzelmann S, Ricklefs FL.
Nature Medicine, 2024, doi: 10.1038/s41591-024-02969-w
Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma.
Drexler R, Khatri R, Schüller U, Eckhardt A, Ryba A, Sauvigny T, Dührsen L, Mohme M, Ricklefs T, Bode H, Hausmann F, Huber TB, Bonn S, Voß H, Neumann JE, Silverbush D, Hovestadt V, Suvà ML, Lamszus K, Gempt J, Westphal M, Heiland DH, Hänzelmann S, Ricklefs FL.
Acta Neuropathologica., 2024, doi: 10.1007/s00401-023-02677-8
Preoperative treatment with dopamine agonist therapy influences surgical outcome in prolactinoma: a retrospective single-center on 159 patients.
Ryba A, Gonzalez Lopez D, Rotermund R, Flitsch J.
Acta Neurochirurgica (Wien), 2024, doi: 10.1007/s00701-024-06198-5
Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features.
Dottermusch M, Ryba A, Ricklefs FL, Flitsch J, Schmid S, Glatzel M, Saeger W, Neumann JE, Schüller U.
Acta Neuropathologica, 2024, doi: 10.1007/s00401-024-02686-1
A multicenter study of clinical outcomes and volumetric trends in suspected microprolactinomas.
Hong CS, Chabros J, Kilgallon JL, Gerstl JVE, Omara C, Drexler R, Flitsch J, Ricklefs FL, Ryba AS, Mazzatenta D, Guaraldi F, Corrales CE, Min L, Smith TR.
Neurosurgical Review, 2024, doi: 10.1007/s10143-024-02951-7
Exoscopic vs. microscopic transsphenoidal surgery for Cushing's disease: a retrospective single-center study on 388 patients.
Sumisławski P, Piffko A, Huckhagel T, Ryba A, Burkhardt T, Aberle J, Saeger W, Flitsch J, Rotermund R.
Neurosurgical Review, 2022, doi: 10.1007/s10143-022-01866-5
Clinico-pathologic predictors of dismal course in atypical meningiomas: a retrospective single-centre analysis.
Ryba A, Millesi M, Roetzer T, Marik W, Wolfsberger S.
Journal of Neurosurgical Sciences, 2022, doi: 10.23736/S0390-5616.22.05741-1
DNA methylation associates with clinical courses of atypical meningiomas: a matched case-control study.
Millesi M, Ryba AS, Hainfellner JA, Roetzer T, Berghoff AS, Preusser M, Heller G, Tomasich E, Sahm F, Roessler K, Wolfsberger S.
Frontiers in Oncology, 2022. doi: 10.3389/fonc.2022.811729
Utility of indocyanine green in the detection of radiologically silent hemangioblastomas: case report.
Ryba AS, Sales-Llopis J, Wolfsberger S, Laakso A, Daniel RT, González-López P.
Journal of Neurosurgery, 2021, doi: 10.3171/2020.8.JNS202176