Gary Kwan Leung Chan
I am a graduate student at UCSF in the Biomedical Science program. In my previous research positions, I helped characterizing the functions and localization of human cytomegalovirus viral proteins, studied the formation and effects of apolipoprotein AI amyloid, and most recently, worked in Gordan Lab at UCSF to uncover potential drug targets for fibrolamellar carcinoma (FLC) and to test if existed drugs can be repurposed as potential treatment for FLC.
Currently, in the setting of glioblastoma, I am interested in studying the roles of transcriptional factors in the epigenomes of CD8+ T-cells, as well as the sources of neoantigens that lead to T cell-tumor cell interactions.
Email: gary.chan@ucsf.edu
2011, B.A. with Honors in Molecular and Cell Biology, University of California, Berkeley
2022, NIGMS IMSD Fellowship
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.
Chan GKL, Maisel S, Hwang YC, Pascual BC, Wolber RRB, Vu P, Patra KC, Bouhaddou M, Kenerson HL, Lim HC, Long D, Yeung RS, Sethupathy P, Swaney DL, Krogan NJ, Turnham RE, Riehle KJ, Scott JD, Bardeesy N, Gordan JD.
Elife. 2023 Jan 24;12:e69521. doi: 10.7554/eLife.69521. PMID: 36692000; PMCID: PMC9925115.
Methionine oxidized apolipoprotein A-I at the crossroads of HDL biogenesis and amyloid formation.
Witkowski A, Chan GKL, Boatz JC, Li NJ, Inoue AP, Wong JC, van der Wel PCA, Cavigiolio G.
FASEB J. 2018 Jun;32(6):3149-3165. doi: 10.1096/fj.201701127R. Epub 2018 Jan 17. PMID: 29401604; PMCID: PMC6137716.
Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I.
Chan GKL, Witkowski A, Gantz DL, Zhang TO, Zanni MT, Jayaraman S, Cavigiolio G.
J Biol Chem. 2015 Apr 24;290(17):10958-71. doi: 10.1074/jbc.M114.630442. Epub 2015 Mar 10. PMID: 25759391; PMCID: PMC4409257.